TO EVALUATE EFFICACY OF ASTHISHRUNKHALA (CISSUS QUADRANGULARIS) ON ACCELERATION OF BONE HEALING IN FRACTURED BONE

Kharik Amol; Morade Swati; Surse Yogesh; Dehankar Manisha

Kharik Amol PG Scholar, Dept. of Shalyatantra, Government Ayurved College and Hospital, Nagpur, Maharashtra
Morade Swati Associate Professor, Dept. of Kriya Sharir, SST Ayurved Mahavidyalaya, Sangamner, Maharashtra
Surse Yogesh Associate Professor, Dept. of Kaumarbhritya, Shree Saptashrungi Ayurved Mahavidyalaya, Nashik
Dehankar Manisha Associate Professor, Dept. of Shalakyatantra, M.S Ayurvedic Medical College, Kudwa, Gondia, Maharashtra

Keywords: Asthishrunkhala, Cissus quadrangularis, Biological bone healing factor, Histopathological study.

Abstract

The healing of a fracture is one of the most remarkable of all the repair processes in the body since results not in a scar but in the actual reconstitution of the injured tissue in something very like its original form. It is not to be expected therefore that the mechanisms controlling such a process will be easily elucidated and indeed they involve problems of cellular homeostasis which are among the most fundamental in biology. If it is not quite thou cunning'st pattern of excelling nature, then it is something quite close to it and a great deal of that pattern.

Present study shows experimental evaluation of effect of Asthishrunkhala (Cissus quadrangularis) on bone healing in fractured bone by histo-pathological study. During study concerned literature was reviewed critically. The study was divided into phytochemical, pharmacological and histopathological study. Drug was identified and authenticated from authorized institute and phytochemical screening done after successive extraction of extract. Two groups were made. First Group A (Treatment group) was further divided into six subgroups containing five animals each received extract of Cissus quadrangularis 500mg/kg body weight, Group B is control group. After completing the study it was observed that mature bone or bone repair process seen weakly at 2^nd– 3^rd week proving the acceleration of bone healing process with gradual re-modeling. Statistical analysis shows that histopathological study in group A found to be highly significant p<0.001 from 4^thweek onwards. Overall the bone healing process shows 10% faster healing period in group A than group B.