THE ANTHELMINTICS EFFECT OF MOMORDICA CHARANTIA L. LEAVES AND ANDROGRAPHIS PANICULATA NESS. FROM INDONESIA

Canny Nur Chastity; Karsa Lugi Yuwono; Ummi Utami; Prala Ayu AP; Wildan Priscillah; Em Sutrisna

Canny Nur Chastity Medical student of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.
Karsa Lugi Yuwono Medical student of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.
Ummi Utami Medical student of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.
Prala Ayu AP Medical student of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.
Wildan Priscillah Medical student of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.
Em Sutrisna Senior lecturer of Department of Pharmacology of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.

Keywords: Momordica charantia L., Andrographis paniculata Ness., Ascaris suum, anthelmintic effect.

Abstract

Momordica charantia L. leaves and Andrographis paniculata Ness. leaves were traditionally used as anthelmintic in Indonesia.

Objective: This study aims at examining the anthelmintic effects of 70% ethanolic extract of Momordica charantia L. leaves and Andrographis paniculata Ness. leaves.

Material and Method: This research was an experimental research with only post test controlled group design. The samples were 72 Ascaris suum worms, divided into 8 groups. The first group was treated by NaCl 0.9% solution as negative control, the second group was treated by pyrantel pamoate as positive control in 0.236 % concentration. The third, fourth and fifth group were treated by 70% ethanolic extract of Momordica charantia L. in 20%, 40%, 80% concentrations respectively. The sixth, seventh and eighth groups were treated by 70% ethanolic extract of Androgaphis paniculata Ness. in 20%, 40% 80% concentrations respectively. Data were collected by observation of total mortality time of Ascaris suum worm every 1 hour. The anthelmintic effects test analysis is performed by Kruskal Wallis test and followed by Mann Whitney test with significancy level at p <0.05.

Result: There are is significant difference between the 70% ethanolic extract of Momordica charantia L (20%, 40%, 80%) and Andrographis paniculata Ness. (20%,40%,80%) with control negative with P value <0.05 by Mann whitney test.

Conclusion: The 70% ethanolic extract of Momordica charantia L. and Andrographis paniculata Ness. leaves have potential as anthelmintic.